If a computer is in an Active Directory Domain environment with Exchange On-Prem installed, Outlook clients might connect to local Exchange instead of Exchange Online, because they query Active Directory first.

This Registry key will avoid SCP Lookup in Active Directory.

HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Outlook\AutoDiscover
DWORD ExcludeSCPLookup 1

If you are curious, SCP is located here (you can view it with ADSIEdit inside the Configuration Partition):

CN=Services, CN=Microsoft Exchange,CN=Organization, CN=Administrative Groups,CN=Exchange Administrative Group, CN=Servers,CN=YourServer,CN=Protocols,CN=Autodiscover,

References:

https://jacob.gardiner-moon.co.uk/2016/06/13/outlook-autodiscover-connecting-local-exchange-server-instead-office-365/